The publication discusses the features of clinical and anamnestic data in adolescents with autonomic dystonia syndrome. Analysis of the health status of children and adolescents in the Youth Center of the city of Tashkent in dynamics for the period 2018-2020 testifies to the persistence of an increase in the incidence of adolescents in socially significant classes of diseases: nervous, cardiovascular, endocrine systems, accompanied by metabolic disorders, arterial hypertension. The growth rate of pathology increases in the adolescent period of ontogenesis. The psychological status of adolescents with ADS demonstrates a high frequency of disorders accompanied by high emotional instability, contributing to social and psychological maladjustment. ADS contributes to the formation of multiple organ pathology, the predominance of disharmonious and sharply disharmonious physical development, inconsistency of body mass index, impaired formation of reproductive health in adolescents with a high frequency of delayed sexual development.